Allele/Variant

Tfr2tm1Slu

Species
Mus musculus
Symbol
Tfr2tm1Slu
Category
allele
Allele of gene
Tfr2
Transgenic Constructs
None
Synonyms
  • TfR2245x
  • Tfr2Y245X
Description
A construct containing a nonsense mutation at codon 245 (in exon 6 and orthologous to human position 250) and a floxed neo cassette in intron 6 was incorporated at the endogenous locus via homologous recombination. Transient transfection of ES cells with cre excised the neo cassette, leaving a single loxP site. Northern blot analysis of total hepatic RNA showed a reduced abundance of normal size transcript in homozygous mutant mice, putatively due to nonsense-mediated decay. Encoded protein was undetected by Western blot analysis.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations