Allele/Variant

Tg(ILK3mHEL)3Ccg

Species
Mus musculus
Symbol
Tg(ILK3mHEL)3Ccg
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • ILK-3
  • ILK-3 Ins-HEL
Description
A genomic fragment containing the coding exons of the chicken lysozyme gene (also known as hen egg lysozyme, HEL) was linked to a 600bp fragment of the rat insulin promoter and to the mouse H2-Kb transmembrane sequence (which included the extracellularspacer sequence, transmembrane segment, and cytoplasmic tail). The rat insulin promoter was used to direct expression of the inserted sequence specifically to pancreatic islet beta cells. Islets from mice carrying the transgene showed expression of chicken lysozyme by Western blot; spleen, thyroid, and thymus did not.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
  • LYZ
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations