Allele/Variant

Mapttm1Hnd

Species
Mus musculus
Symbol
Mapttm1Hnd
Category
allele
Allele of gene
Mapt
Transgenic Constructs
None
Synonyms
  • MaptKO(Duke)
  • TAU-
Description
Exon 1, encoding the translational start site, was replaced by a neomycin selection cassette via homologous recombination. RT-PCR analysis of total brain RNA obtained from homozygous mutant mice showed a lack of transcript produced by the targeted locus. The absence of encoded protein was verified by Western blot analysis of brain homogenates as well as by immunocytochemical analysis of coronal sections.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
    Disease Qualifier
    Disease
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