Allele/Variant

Per3tm1Drw

Species
Mus musculus
Symbol
Per3tm1Drw
Category
allele
Allele of gene
Per3
Transgenic Constructs
None
Synonyms
  • mPER3-deficient
Description
The gene was disrupted by replacement of exon 3 and part of exon 4 (encoding amino acids 92-154) with a PGK-neo cassette via homologous recombination. Introduction of PGK-neo introduces stop codons into all 3 reading frames. Western blot analysis of brain lysates from homozygous mutant animals using antibodies directed against the C-terminus of the protein confirmed the absence of protein expression. Immunoprecipitation assays also confirmed the absence of protein product. Northern blot and RT-PCR analysis detected mutant transcripts containing neo and lacking exon 3 and part of exon 4 in brain and skeletal muscles from homozygous mutants.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal brain wave pattern
MGI
abnormal sleep pattern
MGI
behavioral despair
MGI
shortened circadian behavior period
MGI
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Disease Associations

No data available