Mthfr^tm1Rzn

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Species

Mus musculus

Symbol

Mthfr^tm1Rzn

Category

allele

Allele of gene

Mthfr

Transgenic Constructs

None

Synonyms

• Mthfr^-

Description

Exon 3 was disrupted by the insertion of a neomycin selection cassette. Transcript was undetected by RT-PCR analysis of brain tissue obtained from homozygous mutant mice. Enzymatic activity assays showed a lack of activity in homozygous mutant mice and levels reduced to 60 to 70% of wild-type in heterozygotes.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations