Allele/Variant

Serpinh1tm1Kzn

Species
Mus musculus
Symbol
Serpinh1tm1Kzn
Category
allele
Allele of gene
Serpinh1
Transgenic Constructs
None
Synonyms
  • Hsp47-
Description
The gene was disrupted by replacement of exon 4 and part of exon 5 with a neomycin resistance cassette via homologous recombination. Homozygous mutant embryos were detected by Southern blot up to day E10.5. Homozygous mutant embryos lacked gene expression as demonstrated by RT-PCR and Western blot analysis.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
References
abnormal embryonic neuroepithelium morphologyMGI
abnormal embryonic tissue morphologyMGI
abnormal somite developmentMGI
delayed neural tube closureMGI
embryonic lethality during organogenesis, complete penetranceMGI
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Disease Associations

No data available