Allele/Variant

Igfalstm1Yrb

Species
Mus musculus
Symbol
Igfalstm1Yrb
Category
allele
Allele of gene
Igfals
Transgenic Constructs
None
Synonyms
  • ALSKO
Description
The sequences encoding the first 435 amino acids (including 16 out of 19 leucine repeats) corresponding to exon 1, intron 1, and part of exon 2 were replaced by a neomycin resistance cassette. Northern blot analysis showed an absence of gene transcripts in liver and kidneys of homozygous mutant animals. Plasma proteins from homozygous animals were unable to form cross-linking complexes which is consistent with deletion of the 16 leucine repeats.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
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