Allele/Variant

Ikbkgtm1Mak

Species
Mus musculus
Symbol
Ikbkgtm1Mak
Category
allele
Allele of gene
Ikbkg
Transgenic Constructs
None
Synonyms
  • NEMO(-)
  • NEMO/Ikkgamma-deficient
Description
The gene was disrupted by replacement of exons 1 and 2 with a PGK-neo cassette via homologous recombination resulting in deletion of the first 131 amino acids and a downstream frameshift. Homozygous mutant embryos were detected by PCR genotype analysis up to day E14.5. Western blot analysis of mouse embryonic fibroblasts derived from E12.5 homozygous mutant embryos showed an absence of protein product, thus confirming inactivation of the gene.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations