Allele/Variant

Igf1rtm1Mhz

Species
Mus musculus
Symbol
Igf1rtm1Mhz
Category
allele
Allele of gene
Igf1r
Transgenic Constructs
None
Synonyms
  • IGF-IRneo
Description
Exon 3 was flanked by a floxed neo cassette inserted into intron 2 and a single loxP site in intron 3. Several aberrant transcripts involving the splicing of exon 2 to cryptic slice sites in the neo transgene were identified by RT-PCR and sequence analyses. Further analysis indicated that the readthrough of the neo transgene will result in functional ablation due to truncation or the inclusion of a random neo fragment. Mice carrying this allele were crossed with transgenic mice expressing cre recombinase via the EIIa promoter to generate Igf1rtm1.1Mhz and Igf1rtm1.2Mhz.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
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