Allele/Variant

Kcna4tm1Lndn

Species
Mus musculus
Symbol
Kcna4tm1Lndn
Category
allele
Allele of gene
Kcna4
Transgenic Constructs
None
Synonyms
  • Kv1.4-
Description
The gene was disrupted by replacement of a large part of the coding region with a PGK-neo cassette resulting in the deletion of the N-terminal multimerization domain. Northern blot analysis of brain RNA from homozygous mutant animals detected a truncated transcript, and Western blot analysis failed to detect the 85 kDa protein in the heart or brain. However, a 65 kDa protein was detected that may possibly be another channel protein that cross-reacts with the anti-Kcna4 antibody.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations