Il1rl1^tm1Anjm

---

Species

Mus musculus

Symbol

Il1rl1^tm1Anjm

Category

allele

Allele of gene

Il1rl1

Transgenic Constructs

None

Synonyms

• ST2^-
• T1/ST2^-

Description

Portions of exons 4 and 5 were replaced by a neomycin selection cassette inserted at the endogenous locus via homologous recombination. The deleted region encoded a portion of the extracellular domain which is common to both membrane bound and soluble forms of the protein. RT-PCR analysis of activated lymphocytes showed an absence of normal transcript in homozygous mutant mice. Cell surface expression of the encoded protien was undetected by flow cytometric analysis of cultured mast cells.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations