Allele/Variant

Gata4tm1Sho

Species
Mus musculus
Symbol
Gata4tm1Sho
Category
allele
Allele of gene
Gata4
Transgenic Constructs
None
Synonyms
  • Gata4ki
Description
The endogenous gene was targeted with a construct in which codon 217 had been modified by site directed mutagensis to encode glycine rather than valine. The targeted residue (corresponding with Val 205 in the human protein) lies within the N finger domain and is involved in zinc finger protein binding. A floxed neo cassette was inserted in the intron following the exon containing the substitution mutation. Comparision with mice carrying Gata4tm1.1Sho indicated that the intronic neo cassette did not affect gene expression.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations