Gata4^tm1Sho

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Species

Mus musculus

Symbol

Gata4^tm1Sho

Category

allele

Allele of gene

Gata4

Transgenic Constructs

None

Synonyms

• Gata4^ki

Description

The endogenous gene was targeted with a construct in which codon 217 had been modified by site directed mutagensis to encode glycine rather than valine. The targeted residue (corresponding with Val 205 in the human protein) lies within the N finger domain and is involved in zinc finger protein binding. A floxed neo cassette was inserted in the intron following the exon containing the substitution mutation. Comparision with mice carrying Gata4^tm1.1Sho indicated that the intronic neo cassette did not affect gene expression.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations