Allele/Variant

Xbp1tm1Glm

Species
Mus musculus
Symbol
Xbp1tm1Glm
Category
allele
Allele of gene
Xbp1
Transgenic Constructs
None
Synonyms
  • XBP-1-
Description
A 0.8 kb genomic region between exons 1 and 2 was replaced with a neomycin resistance cassette via homologous recombination resulting in a shift in the downstream reading frame. Northern blot analysis of homozygous mutant embryos did not detect wild-type transcript, but instead detected a larger mutant transcript which contained the neo insert. Western blot of fetal livers did not detect protein product in homozygous mutants.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations