Rgs9^tm1Citb

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Species

Mus musculus

Symbol

Rgs9^tm1Citb

Category

allele

Allele of gene

Rgs9

Transgenic Constructs

None

Synonyms

• RGS9-2 KO
• RGS9^-

Description

A 5.5 kb region containing exons 2-4 (encoding amino acids 19-105) was replaced with a neomycin resistance cassette via homologous recombination. Homozygous mutant animals lacked protein product as determined by Western blot analysis of retinal proteins. Mutant retinas failed to express the long form of G protein, beta 5 (GNB5-L), although normal amounts of its mRNA were still present; however, a normal protein level of the short form GNB5-S was detected in the retina and striatum of mutant mice.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations