Allele/Variant

Il6sttm1Thir

Species
Mus musculus
Symbol
Il6sttm1Thir
Category
allele
Allele of gene
Il6st
Transgenic Constructs
None
Synonyms
  • F759
  • gp130F759
Description
A human Il6st cDNA fragment carrying a tyrosine to phenylalanine substitution at position 759 (Y759F), was used to replaced the corresponding region of the mouse gene. A downstream neomycin resistance cassette was also inserted for positive selection. The expression level of the mutant protein in B- and T-cells is similar to that of wild-type as determined by flow cytometry.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations