Allele/Variant

Runx1tm2Dow

Species
Mus musculus
Symbol
Runx1tm2Dow
Category
allele
Allele of gene
Runx1
Transgenic Constructs
None
Synonyms
  • AML1-ETO
Description
The endogenous locus was targeted with a construct containing human cDNA derived from t(8;21), a translocation observed in leukaemic cells of patients with the M2 subtype of acute myeloid leukemia (AML). The human sequence included 62 bp of exon 4 and all of exon 5 of RUNX1 fused to a portion of CBFA2T1. This RUNX1-CBFA2T1 sequence was fused in frame 95 bp into exon 4 of the endogenous murine gene. Hybrid transcript was detected by RT-PCR analysis of differentiated ES cells.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
    Disease Qualifier
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