Version: 8.0.0Date: Tue Jan 28 2025
Allele/Variant
Tg(SERPINA1-cre/ERT)1Ipc
- Species
- Mus musculus
- Symbol
- Tg(SERPINA1-cre/ERT)1Ipc
- Category
- allele
- Allele of gene
- None
- Transgenic Constructs
- Synonyms
- alphaAT-cre-ERT
- Tg(SERPINA1-cre/ESR1)1Ipc
- Description
- This transgenic construct encodes a tamoxifen-inducible cre recombinase protein. A human SERPINA1 promoter was adjoined to a sequence encoding a fusion protein consisting of cre recombinase and a mutated human estrogen receptor ligand-binding domain, to drive expression in hepatocytes. The ligand-binding domain possesses a substitution mutation at position 521, converting the region from an estradiol binding domain to a tamoxifen binding domain. In situ hybridization and immunohistochemical analysis showed expression in 40% to 50% of hepatocytes.
- Additional Information
- Literature
Transgenic Constructs
This allele contains 1 transgenic construct- Symbol
- Expressed Components
- None
- Knock-down Targets
- None
- Regulatory Regions