Rps6kb1^tm1Gtho

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Species

Mus musculus

Symbol

Rps6kb1^tm1Gtho

Category

allele

Allele of gene

Rps6kb1

Transgenic Constructs

None

Synonyms

• S6K1-

Description

1.2 kb of genomic sequence, including regions encoding the conserved serine threonine kinase catalytic subdomains 8 through 10, was replaced with a neomycin selection cassette by homologous recombination. Western blot analysis of homozygous mutant mice using two antibodies directed to the amino and carboxy termini showed an absence of protein. A kinase phosphorylation assay showed no activity in homozygous mutant mice verifying a complete functional ablation.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations