Allele/Variant

Tg(CMV-cre/ERT)1Ipc

Species
Mus musculus
Symbol
Tg(CMV-cre/ERT)1Ipc
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • CMV-cre
  • CMV-CRE-ER-Tx
Description
The transgenic construct encodes a tamoxifen-dependent cre recombinase. The cre recombinase coding region was joined to a sequence encoding the ligand-binding domain of the human estrogen receptor with glycine to arginine missense mutation at position 521. This substitution enables the domain to bind to tamoxifen while ablating the estradiol binding ability. The transgene was driven by the CMV promoter.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
None
Knock-down Targets
None
Regulatory Regions
  • CMV
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
    Disease Qualifier
    Disease
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