Allele/Variant

St6gal1tm1Jxm

Species
Mus musculus
Symbol
St6gal1tm1Jxm
Category
allele
Allele of gene
St6gal1
Transgenic Constructs
None
Synonyms
  • ST6Galdelta
Description
Exon 2 was flanked by loxP sites and a loxP-tk-neo cassette was inserted into the upstream intron via homologous recombination. Transient expression of cre recominase in correctly targeted cells facilitated the removal of exon 2 and the loxP-tk-neo cassette. The mutation deletes the cytoplasmic, tranmembrane, and the majority of the catalytic domains. Enzymatic analysis of liver and spleen extracts from homozygous mutant animals showed no detectable enzyme activity.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations