Allele/Variant

Tg(HCRT-MJD)1Stak

Species

Mus musculus

Symbol

Tg(HCRT-MJD)1Stak

Category

allele

Allele of gene

None

Transgenic Constructs

Synonyms

orexin/ataxin-3
ORX/ATX-Tg

Description

The transgenic construct contained a carboxy terminal MJD cDNA fragment derived from a patient with Machado-Joseph disease adjoined to a human HCRT promoter. The promoter region consisted of 3.2 kb of 5' upstream region in addition to the the noncoding exon 1. Expression was directed specifically in hypocretin neurons. The MJD fragment contained 77 polyglutamine repeats and was tagged with a Myc epitope tag for histological examination. Expression of the MJD fragment resulted in the ablation of hypocretin containing neurons

Additional Information

Literature

Transgenic Constructs

This allele contains 1 transgenic construct

Symbol

Expressed Components

ATXN3 (Hsa)

Knock-down Targets

None

Regulatory Regions

None

All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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Disease Associations

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