Rad50^tm2Jpt

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Species

Mus musculus

Symbol

Rad50^tm2Jpt

Category

allele

Allele of gene

Rad50

Transgenic Constructs

None

Synonyms

• Rad50^K22M
• Rad50^S

Description

An engineered A to T mutation in exon 1 (c.65A>T) results in a lysine to methionine substitution at amino acid 22 in the encoded peptide (p.K22M). A floxed puromyin resistance gene cassette was inserted upstream of exon 1. The puro cassette was excised by crossing mutant animals to the cre-expressing line Tg(CMV-cre)1Nagy.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations