Sod1^tm1Dkd

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Species

Mus musculus

Symbol

Sod1^tm1Dkd

Category

allele

Allele of gene

Sod1

Transgenic Constructs

None

Synonyms

• Cu/ZnSOD-KO
• Sod 1^-

Description

The gene was disrupted by replacement of exon 5 and flanking intronic sequences with a neomycin resistance cassette via homologous recombination. The mutation deletes C-terminal amino acids 120-154 which constitute the structure and function of the active site channel. Absence of gene expression in homozygous mutant animals was confirmed by Northern blot analysis of heart tissue.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations