Eif2ak4^tm1Drc

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Species

Mus musculus

Symbol

Eif2ak4^tm1Drc

Category

allele

Allele of gene

Eif2ak4

Transgenic Constructs

None

Synonyms

• Gcn2-Neo
• Gcn2^-

Description

The majority of exon 12, which encodes the kinase subdomains 2 through 4 common to the 3 known isoforms (alpha, beta, and gamma), was replaced by a neomycin selection cassette inserted by homologous recombination. While, RT-PCR analysis showed the presence of an aberrant splice product, sequence analysis showed it generated a frameshift mutation in the open reading frame. Western blot analysis verified the absence of protein.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations