Allele/Variant

Tgfbr1tm1Karl

Species
Mus musculus
Symbol
Tgfbr1tm1Karl
Category
allele
Allele of gene
Tgfbr1
Transgenic Constructs
None
Synonyms
  • Alk5-
  • TbetaRI-
Description
A single loxP site remained in place of exon 3 after an upstream floxed neo cassette and downstream loxP site were recombined by transient expression of cre recombinase in targeted ES cells. The mutation results in deletion of the transmembrane domain and the GS domain required for protein function. Northern blot analysis using a full-length cDNA probe did not detect transcripts in endothelial cells from homozygous mutant embryos.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
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