Cd79a^tm1.1Cgn

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Species

Mus musculus

Symbol

Cd79a^tm1.1Cgn

Category

allele

Allele of gene

Cd79a

Transgenic Constructs

None

Synonyms

• Igalpha^FF

Description

This allele is derived from Cd79a^tm1Cgn by crossing mutant animals to a cre deleter line. Cre-mediated recombination results in removal of the floxed region containing endogenous exons 4-5. The deletion leaves behind duplicated exons carrying tyrosine to phenylalanine mutations at positions 182 and 193 of the ITAM motif. The correct sequence of the amino acid substitutions in mutant animals was verified by sequence analysis.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations