Version: 8.0.0
Date: Tue Jan 28 2025
Klk8tm1Lth
MGI:2388384
Allele of Klk8
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Klk8tm1Lth

Species
Mus musculus
Symbol
Klk8tm1Lth
Category
allele
Allele of gene
Klk8
Transgenic Constructs
None
Synonyms
None
Description
The gene was disrupted by replacment of the region of exon 3 encoding the aspartic acid region of the catalytic site with a lacZ-neo cassette. The targeting construct introduces stop codons in all 3 reading frames. Northern blot analysis of brain RNA verified the absence of gene expression in homozygous mutant animals. X-gal staining of mutant brains did not detect any lacZ expression.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
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