Allele/Variant

Il6sttm1Ern

Species
Mus musculus
Symbol
Il6sttm1Ern
Category
allele
Allele of gene
Il6st
Transgenic Constructs
None
Synonyms
  • gp130757F
  • gp130F
Description
The Ptpn11 binding domain, encoded by sequence in exon 17, was disrupted by homologous recombination of a construct containing missense mutations at codons 757 (tyrosine to phenylalanine) and 760 (valine to alanine). Furthermore, an IRES-neo cassette was inserted into the 3' region of exon 17. A biochemical assay of liver tissue showed that the Il6st mediated signalling pathway was disrupted in mutant mice.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations