Allele/Variant

Lattm1.1Lov

Species
Mus musculus
Symbol
Lattm1.1Lov
Category
allele
Allele of gene
Lat
Transgenic Constructs
None
Synonyms
  • LATY136Fm
Description
Animals carrying the mutation Lattm1Lov were crossed to a cre-expressing line to excise the floxed neomycin cassette, leaving behind the tyrosine to phenylalanine substitution at position 136 (Y136F), and resulting in the mutant line Lattm1.1Lov. Residue 136 is critical for Plcg1 binding. Presence of the mutant allele and the integrity of the gene were confirmed by sequence analysis.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations