Allele/Variant

Trp53tm1Mok

Species
Mus musculus
Symbol
Trp53tm1Mok
Category
allele
Allele of gene
Trp53
Transgenic Constructs
None
Synonyms
None
Description
The gene was disrupted by replacment of exons 2-10 with a neo-TK cassette via homologous recombination. Germline founder animals were established but did not transmit the mutant allele to offspring, indicating a 100% segregation distortion. Authors hypothesize the HSV-TK gene is responsible for the lack of allele transmission.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

No data available

Disease Associations