Allele/Variant

Csf3rtm4(Epor)Link

Species
Mus musculus
Symbol
Csf3rtm4(Epor)Link
Category
allele
Allele of gene
Csf3r
Transgenic Constructs
None
Synonyms
  • G:EpoR
  • GE
Description
Exons 16 and 17 of the endogenous gene, which encode the cytoplasmic domain, were replaced by an Epor cDNA fragment. The resultant allele encodes a chimeric receptor with the endogenous extracytoplasmic (ligand binding) and transmembrane regions adjoined to the Epor cytoplasmic (signaling) region. Flow cytometric and ligand binding assays indicated that the chimeric receptor had normal binding affinity and was expressed on the surface of homozygous mutant neutrophils at a level approximately 80% of normal expression.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations