Allele/Variant

Camk2atm1Mllr

Species
Mus musculus
Symbol
Camk2atm1Mllr
Category
allele
Allele of gene
Camk2a
Transgenic Constructs
None
Synonyms
None
Description
The endogenous 3' UTR was replaced with a bovine growth hormone 3' UTR. The bovine sequence contains an identical polyadenylation hexanucleotide but lacks a dendritic localization signal. In situ hybridization of mutant brain sections indicated that dendritic localization was disrupted. Quantification of the hybridization results showed reduced expression levels in hippocampal cell bodies (approximately 85.3% of wild-type).
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations