Allele/Variant

Tg(CMV-IgkvaD11)ACat

Species
Mus musculus
Symbol
Tg(CMV-IgkvaD11)ACat
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • AD10 A
  • AD11-VK
Description
The transgenic construct included a recombined Igk variable region encoding the light chain of the rat anti-nerve growth factor monoclonal antibody, alphaD11. The human immunoglobulin kappa constant region (IGKC) was included downstream to enable the detection of the transgenic antibodies against murine immunoglobulins. The early region promoter (-601 to -16) of human CMV reportedly drove expression of the transgene in non-neuronal tissures as well as in neuronal tissues including the cortex, hippocampus, thalamus, spinal cord, retina, olfactory bulb, and cerebellum. Line A produces lower expression of the light chain transgene than line B.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
  • Igkv
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

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    Disease Associations

    Association
    Disease Qualifier
    Disease
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