Allele/Variant

Tbxa2rtm1Cof

Species
Mus musculus
Symbol
Tbxa2rtm1Cof
Category
allele
Allele of gene
Tbxa2r
Transgenic Constructs
None
Synonyms
  • Tp-
  • TPKO
Description
The insertion of a PGK-neo cassette into exon 2 disrupted sequence encoding the third transmembrane domain. Though Northern blot analysis identified several aberrant transcripts in homozygous mutant mice, no normal transcript was detected. Binding assays using a labeled thromboxane agonist indicated an absence of functional receptors in both thymocytes and renal sections obtained from homozygous mutant mice.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations