Selp^tm2Hyn

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Species

Mus musculus

Symbol

Selp^tm2Hyn

Category

allele

Allele of gene

Selp

Transgenic Constructs

None

Synonyms

• DeltaCT

Description

The endogenous locus was disrupted by homologous recombination of a construct containing two engineered stop codons followed by a human growth hormone (hGH) polyadenylation signal and neo. The stop codons were inserted after the first 9 nt encoding the cytoplasmic domain. In spite of the detection of both truncated and elongated transcripts by Northern blot analysis, Western blot analysis showed an absence of cytomplasmic domain peptide sequence in platelet and lung tissue lysates obtained from homozygous mutant mice.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations