Allele/Variant

Tg(GFAP-TAg121)1Tvd

Species
Mus musculus
Symbol
Tg(GFAP-TAg121)1Tvd
Category
allele
Allele of gene
None
Transgenic Constructs
None
Synonyms
  • G(deltaZ)T121
  • GdeltaZT121
Description
This allele was derived from mating Tg(GFAP-lacZ-TAg121)92Tvd animals to mice carrying a cre transgene (Tg(ACTB-cre)2Mrt). As a result the intervening floxed lacZ cassette was removed, leaving a single loxP site and allowing transcription from the mutant SV40 T antigen sequence. The mutant SV40 T antigen 121 contains a deletion for the small t antigen-specific splice signal and a deletion that results in truncation of the large T antigen at amino acid 121. The mutant antigen binds RB1/RBL1/RBL2 but not TRP53. Immunohistochemical analysis of progeny showed diffuse expression of this transgene throughout the brain.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
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