Calca^tm1Hku

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Species

Mus musculus

Symbol

Calca^tm1Hku

Category

allele

Allele of gene

Calca

Transgenic Constructs

None

Synonyms

• alphaCGRP^-
• CGRP^-

Description

The alphaCGRP sequence was disrupted by replacement of exon 5 with a PGK-neo cassette leaving the calcitonin (CT) sequence uninterrupted. RT-PCR analysis confirmed the absence of alphaCGRP expression in mutant mice while CT expression appears unaffected. Immunohistochemical analysis did not detect alphaCGRP protein in the spinal cords of mutant animals, but thyroid gland samples stain positive for CT.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations