Mybl2^tm1Sis

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Species

Mus musculus

Symbol

Mybl2^tm1Sis

Category

allele

Allele of gene

Mybl2

Transgenic Constructs

None

Synonyms

• B-myb^-

Description

Exon 5, which encodes amino acids 94 through 167, was replaced by the insertion of a neomycin selection cassette. The deleted region encompassed portions of repeats 2 and 3 that are involved in DNA binding. Whereas this allele was observed to be homozygously lethal, similar amounts of protein were detected by Western blot analysis of wild-type and heterozygous mice.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations