Version: 8.0.0
Date: Tue Jan 28 2025
Tg(Camk2a-Fyn-531)1Nko
MGI:2446470Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tg(Camk2a-Fyn-531)1Nko

Species
Mus musculus
Symbol
Tg(Camk2a-Fyn-531)1Nko
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • fyn+
Description
The transgene consists of a Camk2a promoter fused to a Fyn isoform B cDNA carrying a TAT to TTT nucleotide substitution at codon 531. Camk2a drives expression in forebrain neurons late in development. This mutation renders Fyn constitutively activated. Transgene expression in the brain was confirmed by Northern blot, RNase protection assay, RT-PCR, and in situ hybridization.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
    Source
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