Version: 8.0.0
Date: Tue Jan 28 2025
Tg(Prnp)a19Cwe
MGI:2447132Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tg(Prnp)a19Cwe

Species
Mus musculus
Symbol
Tg(Prnp)a19Cwe
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • Tg(Prnp)19Cwe
  • tga19
Description
This transgene encodes a wild-type murine Prnp gene. Expression studies demonstrate that this line expresses Prnp transcripts in the brain 4- to 5 fold compared to wild-type. Expression patterns were similar to wild-type mice with the notable exception that transcript was not detected in Purkinje Cells. This transgenic construct, referred to as 'half genomic' was designed to omit a large intron in order to facilitate subsequent mutagenesis studies. Transgenic line 19 carries 30 copies of the integrated transgene.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
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