Allele/Variant

Tg(THY1-APP)2Somm

Species
Mus musculus
Symbol
Tg(THY1-APP)2Somm
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • APP 22
Description
A human THY1 promoter and a human APP sequence carrying mutations found in Alzheimer's disease patients (Swedish double mutation K670M and N671L and London mutation V717I) was used for the transgene. In situ hybridization analysis of brain sections from transgenic animals showed the highest levels of transgene expression in the neocortex and hippocampus.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
Knock-down Targets
None
Regulatory Regions
None
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
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