Version: 8.0.0
Date: Tue Jan 28 2025
Tg(SFTPC-RAF1-BxB)1Urr
MGI:2447567Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tg(SFTPC-RAF1-BxB)1Urr

Species
Mus musculus
Symbol
Tg(SFTPC-RAF1-BxB)1Urr
Category
allele
Allele of gene
None
Transgenic Constructs
None
Synonyms
  • SP-C-c-raf-1-BxB
  • SP-C-craf BxB-23
Description
The transgene is composed of a human SFTPC promoter, a human mutant RAF1 cDNA, and an SV40 small T antigen intron and polyadenylation signal. The mutant RAF1 sequence is deleted for the N-terminus and is constitutively active and highly transforming. 3.7 kb of human SFTPC promoter sequences was used to drive transgene expression in lung epithelium. The transgene is highly expressed in lungs as observed by Western blot analysis. The transgene is also weakly expressed in kidneys.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
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