Pold1^tm1Bdp

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Species

Mus musculus

Symbol

Pold1^tm1Bdp

Category

allele

Allele of gene

Pold1

Transgenic Constructs

None

Synonyms

• exo-
• Pold1^D400A

Show All 3

Description

A point mutation resulting in an aspartic acid to alanine substition at residue 400 (D400A) was introduced at the endogenous locus by homologous recombination of a targeting vector also carrying an intronic neo cassette. The missense mutation was introduced into sequence encoding the proofreading domain. RT-PCR analysis of heterozygous ES cells showed comparable levels of wild-type and mutant transcript. Western blot analysis of fibroblasts derived from mutant mice further indicated normal levels of expression.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations