Allele/Variant

Tg(Camk2a-cre/PGR*)1Gsc

Species
Mus musculus
Symbol
Tg(Camk2a-cre/PGR*)1Gsc
Category
allele
Allele of gene
None
Transgenic Constructs
Synonyms
  • CPR1
  • Tg(Camk2a-cre/PGR)1Gsc
Description
This transgene expresses a fusion protein consisting of Cre recombinase and a modified ligand binding domain of the human progesterone receptor under the control of a mouse calcium-calmodulin-dependent kinase IIa promoter. The ligand binding domain was modified such that it binds and can be activated by the synthetic steroid, RU486, but not the endogenous ligand, progesterone. Upon induction of transgene expression with RU486, activity was noted in the hippocampus and cortex.
Additional Information
Literature

Transgenic Constructs

This allele contains 1 transgenic construct
Symbol
Expressed Components
None
Knock-down Targets
None
Regulatory Regions
All alleles with this construct

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
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