Version: 8.0.0Date: Tue Jan 28 2025
Allele/Variant
Tg(Mx1-IL11)1Tku
- Species
- Mus musculus
- Symbol
- Tg(Mx1-IL11)1Tku
- Category
- allele
- Allele of gene
- None
- Transgenic Constructs
- Synonyms
- None
- Description
- An inducible Mx1 promoter and a 762 bp DNA fragment containing the coding region of human IL11 was used for the transgene. The Mx1 promoter was included for transgene induction by interferon alpha/beta. Since the transgenic animals constitutively expressed human IL11, interferon induction was not implemented. The 3' untranslated region of the transgene contains exons, introns, and polyadenylation sequences from human GH. Transgene expression is constitutively active in several tissues examined by RT-PCR. Furthermore, Northern blot analysis detected transgene expression in the long bone of transgenic animals.
- Additional Information
- Literature
Transgenic Constructs
This allele contains 1 transgenic construct- Symbol
- Expressed Components
- Knock-down Targets
- None
- Regulatory Regions
- None