Version: 8.0.0
Date: Tue Jan 28 2025
Tns2nph
MGI:2447990
Allele of Tns2
Mus musculus
SummaryTransgenic ConstructsGenomic Variant InformationVariant Molecular ConsequencesPhenotypesDisease Associations
Allele/Variant

Tns2nph

Species
Mus musculus
Symbol
Tns2nph
Category
allele
Allele of gene
Tns2
Transgenic Constructs
None
Synonyms
  • nep
  • Tns2ICGN
Description
A phenotypic mutant that arose in an outbred ICR colony at the National Institute of Health (Japan) in 1986. This is the main causative gene producing nephrosis in the ICGN strain. An 8 base pair deletion in exon 18 (NM_001355636.1:c.1546_1553delTCATCCAC GRCm39:chr15:102019657-102019684delTCATCCAC) causes a frameshift and premature stop codon (p.S516Afs*19). Tenc1 expression is significantly decreased in all organs of ICGN animals.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

No data available

Phenotypes

Phenotype
Annotation details
Source
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    Disease Associations

    Association
    Disease Qualifier
    Disease
    Annotation details
    Evidence
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