Allele/Variant

Scnn1btm1.1Ipt

Species
Mus musculus
Symbol
Scnn1btm1.1Ipt
Category
allele
Allele of gene
Scnn1b
Transgenic Constructs
None
Synonyms
  • beta566Stop
  • Liddle
Description
The mouse model of Liddle's syndrome was created by deleting the loxP-flanked neomycin resistance cassette following the engineered stop codon at position 566. This was achieved by mating Scnn1btm1Ipt animals to cre-expressing line TgN(EIIa-cre)C5379Lmgd. Northern blot analysis of colon and kidney mRNA showed a significant decrease in gene expression in mutant animals.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations