Allele/Variant

Btktm1Gsv

Species
Mus musculus
Symbol
Btktm1Gsv
Category
allele
Allele of gene
Btk
Transgenic Constructs
None
Synonyms
  • Btk-
Description
A vector was constructed that contained an in-frame fusion of 1.5 kb 5' genomic sequences of the targeted gene (up to exon 8) to the nuclear localization signal (nls) of the SV40 T antigen and the E. coli lacZ gene. After homologous recombination in ES cells, only exons 1 - 7 of the targeted gene were intact and were fused to the lacZ reporter. Western blots of total cell lysates from spleen cells and from thymocytes showed no detectable protein for the targeted gene in hemizygous mutant male mice.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations