Erbb2^{tm3(Erbb2)Mul}

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Species

Mus musculus

Symbol

Erbb2^{tm3(Erbb2)Mul}

Category

allele

Allele of gene

Erbb2

Transgenic Constructs

None

Synonyms

• ErbB2^Flox

Description

Exon 1 was replaced with a loxP-flanked rat Erbb2 cDNA followed by a neomycin selection cassette. Immunoprecipitation and western blot analysis demonstrated that a reduced level of expressed protein was present in muscle extracts derived from homozygous mice. Crossing mice carrying this allele with mice expressing Cre recombinase is expected to eliminate expression from this allele.

Additional Information

Literature

Transgenic Constructs

Genomic Variant Information

Variant Molecular Consequences

Phenotypes

Disease Associations