Allele/Variant

Hcn2tm1Ldw

Species
Mus musculus
Symbol
Hcn2tm1Ldw
Category
allele
Allele of gene
Hcn2
Transgenic Constructs
None
Synonyms
  • HCN2-
Description
A floxed neo cassette and a single loxP site flanking exons 2 and 3 were introduced via homologous recombination. The floxed neo cassette and exons 2 and 3 were removed by transient expression of cre recombinase in correctly targeted cells, resulting in deletion of sequences encoding 5 of the 6 transmembrane segments of the Hcn2 channel as well as part of the pore. Absence of gene expression was confirmed by Northern and Western blot analysis of brain extracts from homozygous mutant animals.
Additional Information
Literature

Transgenic Constructs

No data available

Genomic Variant Information

No data available

Variant Molecular Consequences

Phenotypes

Disease Associations